thesis on drug development

The present master thesis will offer a scientific overview of the topic regarding preclinical studies in drug development, with a particular focus on the translational process from animals to humans and the potential obstacles which are necessary to be overcome. Translational

biological targets · drug design · organic synthesis 1. Introduction The recent successes of the pharmaceutical enterprise are undeniable and extraordinary. Admirable as it is, the drug discovery and development process is one of the most challenging and difficult human endeavors, for it has to balance efficacy in health benefits with safety ...

of innovative drug development (i.e. the development of NME's working through new mechanisms of action) exist that have proven to reduce development costs and risks. They have worked without having to substantially increase WIP to compensate for the risky, cost- and time-intensive endeavor of creating first-in-class NME's.

The drug development process consists of two stages - pre-clinical studies, which are done in laboratories and on animals, and clinical trials, which further test drug safety and efficacy on human beings. Also, first-to-market drugs typically enjoy significantly greater market shares than drugs launched later to the

The thesis entitled "computer-aided drug design approaches in developing anti-cancer drug" is divided into a total of six chapters. In the first chapter, an overview of drug discovery and development are introduced. Nowadays, drug discovery and development has clearly changed

Within Early Drug Development In this thesis, there is first a brief introduction for people unfamiliar with the field and then a presentation of three projects related to early drug discovery for which computational methodology was used. Papers I-III concern an early drug discovery project that focused on the protein target 1-deoxy-D-xylulose-

Drug discovery and development relies on construction and selection of small organic compounds or biological agents that bind targets of interest. This thesis includes new methodology to ...

effects of the Orphan Drug Act (ODA) on pharmaceutical availability. The ODA included a number of incentives to encourage the development of drugs against "orphan diseases" - diseases with a prevalence less than 200,000 cases in the U.S. These incentives have been viewed as a model for effective policy and have been widely imitated globally.

A Doctoral Thesis at a university in Sweden is produced either as a monograph or as a collection of papers. In the latter case, the introductory part constitutes the formal thesis which summarizes the accompanying papers. These have either already been published or are ... Drug development has been classically associated with large

2002, 2). In other words, the focus of this thesis is on new drug development. 2.1 Overview of biotechnology industry At the centre the biotech industry are the direct participants such as start-ups, established companies, investors and customers. These core players are linked