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  6. Organization and expression of Ig genes

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COMMENTS

  1. Evidence for somatic rearrangement of immunoglobulin genes …

    N Hozumi, S Tonegawa. PMID: 824647. PMCID: PMC431171. DOI: 10.1073/pnas.73.10.3628. Abstract. A high-molecular-weight DNA from Balb/c mouse early embryo or from MOPC 321 …

  2. SOMATIC GENERATION OF IMMUNE DIVERSITY

    Putative recognition sequences for the rearrangement of immunoglobulin and T cell receptor genes. The conserved heptamer and nonamer sequences and the length of the spacer …

  3. Chapter 23: Immunology

    The Experiment. Tonegawa realized that if immunoglobulin genes underwent rearrangement, then the V and C genes were most likely located at different points in the genome. The discovery of restriction endonucleases, enzymes …

  4. Building antibody diversity

    In 1976, a key paper by Hozumi and Tonegawa provided experimental evidence for the somatic rearrangement of immunoglobulin genes.

  5. That Great Time in Basel Commentary

    the Hozumi and Tonegawa experiment (Tonegawa et al., 1977a). This marked the beginning of a series of truly exciting discoveries that came out of our collaboration during the subsequent …

  6. Evidence for somatic rearrangement of immunoglobulin genes …

    Susumu Tonegawa. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. 1976 [classical article]

  7. Milestone 10: Building antibody diversity

    In 1976, a key paper by Hozumi and Tonegawa provided experimental evidence for the somatic rearrange-ment of immunoglobulin genes.

  8. Tonegawa Laboratory

    Differentiation of Immunoglobulin Genes S. Tonegawa and N. Hozumi Introduction the technology Of particular the availability of highly purified, Light and heavy mRNAs from ncuse …